Architecture

The Anchor-Gate-Target (AGT) System.

"A modular, programmable architecture replacing the 'Always-ON' toxicity of standard chemotherapy with binary OFF/ON states."

Mechanism of Action (Scroll Animation)

Step 1: (Circulation) Stealth Mode.

"Zwitterionic Peptide Shielding is designed to prevent opsonization and non-specific interaction in serum environments."

Step 2 : (Activation) The Logic Check.

"The platform detects high concentrations of MMP-9 enzymes—a hallmark of the Tumor Microenvironment (TME)—to physically trigger the gate."

Step 3 : (Uptake) The Breach.

"The shield sheds ('Fly-Away' effect), exposing the cationic surface for targeted uptake and matrix retention."

Caption :

Figure 1: Mechanism of action for proteolytically activated liposomal delivery.

Platform Validation

"Fluorescence Activation in MMP-9 vs. Serum Stability").

"Current in-vitro studies demonstrate robust logic-gating: constructs remain inert in serum (OFF state) and exhibit rapid activation only in the presence of MMP-9 (ON state). Our computational in-silico modeling predicts a high therapeutic index for solid tumor applications."